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How do keratinocytes on the surface of the skin remain tightly interconnected?

  1. Melanin

  2. Desmosomes

  3. Collagen

  4. Elastin

The correct answer is: Desmosomes

Keratinocytes on the surface of the skin remain tightly interconnected through desmosomes. Desmosomes are specialized structures that act as strong anchors between adjacent cells, preventing them from separating and creating a tight barrier on the skin surface. Melanin, collagen, and elastin do not play a role in interconnecting keratinocytes. Melanin determines skin color, collagen provides structural support to the skin, and elastin allows it to stretch and return to its original shape. However, none of these substances specifically help keratinocytes remain tightly interconnected. Therefore, B is the correct answer as it directly addresses the mechanism responsible for the tight connection between keratinocytes.